Angiogenic markers during preeclampsia: Are they associated with hypertension 1 year postpartum?

Preeclampsia is associated with hypertension in later life, but the underlying pathophysiological mechanisms remain uncertain. We aimed to explore whether angiogenic markers soluble Fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) measured women preeclampsia could be 1 year after delivery. This a secondary analysis of prospective cohort study, originally evaluate use sFlt-1/PlGF ratio predict adverse outcome (suspected) preeclampsia. Office blood pressure (BP) was evaluated at postpartum who had confirmed diagnosis within one week biomarker measurement. Eighty were included median (interquartile range) gestational age (GA) measurement 30 (27–33) weeks. Twenty-three (29%) postpartum. These showed higher SBP during their pregnancy lower GA PE compared without hypertension. Median PlGF levels (23 vs. 48 pg/mL, p = 0.017), while no differences sFlt-1 or observed. Multivariable adjusted for did not show significant association between (nor sFlt-1, ratio) (OR [95% CI] 0.9 [0.2–4.4], 0.97). Our data indicate that are suitable prediction hence guiding follow-up previous